Valacyclovir (Valtrex) 500mg x 100 – Canadian Pharmaceutical Grade

Description

Valacyclovir 500mg x 100 – Canadian Pharmaceutical Grade

. How it works

• Valacyclovir is used to treat cold sores, genital herpes, herpes zoster, and chickenpox.
• Valacyclovir an antiviral prodrug that is rapidly converted into acyclovir inside the body. Acyclovir has activity against several different viruses including herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). These viruses cause illnesses such as chickenpox, cold sores, genital herpes, and shingles.
• Valacyclovir mechanism involves preventing the virus from replicating in 3 different ways: competitive inhibition of viral DNA polymerase, incorporation and termination of the growing viral DNA chain, and inactivation of the viral DNA polymerase. Activity against HSV is greater than activity against VZV. Also exhibits activity against other viruses that do not code for this enzyme.
• Valacyclovir belongs to the drug class called antivirals.

2. Upsides

• Used to treat viral infections caused by herpes and varicella-zoster viruses, such as genital herpes, cold sores, shingles, and chickenpox.
• Active against herpes viridae including herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), and cytomegalovirus.
• Approved to treat cold sores in children aged 12 and older and chickenpox in children aged two to 18 years.
• Does not cure genital herpes or completely rid the body of the herpes or varicella-zoster virus.
• Valacyclovir is an oral tablet (500 mg) that only needs to be taken twice daily, compared to five times daily for acyclovir. This makes it more convenient for people to take. Treatment may last from one to 14 days depending on the condition being treated and the immunocompetency of the person being treated.
• For cold sores, the dosage is 2 grams every 12 hours for 1 day. Treatment for cold sores should not exceed one day.
• May be taken with or without food.
• Valacyclovir is better absorbed than acyclovir. This results in concentrations in the body that are comparable to those achieved with IV acyclovir.
• Does not appear to have any clinically significant drug-drug or drug-food interactions.
• Not metabolized by hepatic CYP enzymes.
• Generic valacyclovir is available.

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